The dressing will show if there is a bacterial infection

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Scientists have developed a new type of dressing that can signal the development of a bacterial infection. The paper band also indicates whether bacterial strains are sensitive to antibiotics or drug resistant, which requires a different type of treatment.

Dressing, named by its creators portable paper-based band-aid (PBA), under the influence of developing bacteria, it changes color. In the case of a clean wound or one where the amount of bacteria does not threaten the development of infection, the bandage remains green. If the dressing turns yellow, it means that the wound was attacked by antibiotic-sensitive strains. Red is a signal that drug-resistant bacteria have entered and administration of the antibiotic alone will not help, additional surgical intervention or other supportive method may be required.

The dressing was developed by a team of Chinese scientists from the Chemical Biology Laboratory and the State Key Laboratory for Rare Earth Resources and the Changchun Institute of Applied Chemistry at the Chinese Academy of Sciences. In the article published by American Chemical Society, the authors of the idea cite death statistics resulting from antibiotic resistance:

There are 700,000 deaths worldwide each year due to the body being attacked by drug-resistant microorganisms. Accelerated emergence and widespread development of antibiotic resistant bacterial strains is one of the most serious threats to human health in the world. However, antibiotics, with their pronounced antibacterial mechanisms, are still the most commonly used treatment. Due to the "automatic aging" of antibacterial treatment, the rational use of existing antibiotics and breaking tolerance is an important issue in the current antibacterial field. Early detection of bacterial infections and tracking the emergence of drug resistance are essential preconditions for choosing treatment regimens.

The color-changing dressing helps to quickly recognize bacterial infections, which may be asymptomatic at first. A quick response will minimize the risk of infection and at the same time prevent the administration of antibiotics in the dark, which leads to the development of drug resistance. It is important that the infection is visible to the naked eye.

dressing
PBA was conceived so that the intensity of the color indicates the concentration of bacteria. The stronger the color, the higher the concentration of bacteria. The top row is antibiotic sensitive (DS sensitive) bacteria. The bottom row is drug resistant (DR).

By testing the bandage on mice, the research team was able to successfully cure bacterial infection E. coli, both sensitive and resistant to drugs.

When drug resistance is detected, Chinese scientists propose the use of an intense light beam that is supposed to activate the release of highly reactive oxygen species to weaken bacteria, making them more susceptible to the antibiotic that the dressing is soaked in. PBA is not only a dressing sensitive to infections, but also immediately prepared to fight them.

Health care institutions do not care enough about the patient being treated with antibiotics. Most primary care physicians in controlled entities prescribed antibiotics without appropriate microbiological tests. Moreover, they were also treated for infections whose clinical picture indicated that they could be caused by viruses. At the same time, there are more and more patients infected with drug-resistant strains of bacteria in hospitals. The data of the National Health Fund show that currently the probability of death of a patient infected in a hospital with a drug-resistant bacterium is 8 times higher than in the case of an uninfected patient.
Fragment of the article "Antibiotics and what's next: published on the website Supreme Audit Office.

The World Health Organization has been monitoring the growing problem of bacterial drug resistance for several years. In cooperation with FAO (United Nations Food and Agriculture Organization) and OIE (World Organization for Animal Health), WHO collects data in the system Global Antimicrobial Surveillance System (GLASS). Bacterial strains resistant to standard antibiotics were found in 500,000 sick in 22 countries. The most frequently detected bacterial species that have developed drug resistance are: Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae and Salmonella spp. GLASS does not include drug-resistant TB. | allthingsblogging.com

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